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    Background Dysfunctional adipose tissue (AT) is known to contribute to the pathophysiology of metabolic disease, including type 2 diabetes mellitus (T2DM). This dysfunction may occur, in part, as a consequence of gut-derived endotoxaemia inducing changes in adipocyte mitochondrial function and reducing the proportion of BRITE (brown-in-white) adipocytes. Therefore, the present study investigated…

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    • 'Gut-derived #endotoxaemia contributes to both adipocyte dysfunction and reduced browning capacity of #adipocyte cell population, exacerbating #metabolic consequences.' Implications for #BariatricSurgery by Omran et al. @BMSatWarwick @NTUBIOSCIENCES https://t.co/qxaIQcfR3O https://t.co/nbykm1RIpZ

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    Energy storage is a crucial physiological process for all metazoans, the mechanisms of which are at least partially conserved across the animal kingdom. Lipid-storing adipocytes, the major constituent cell type of adipose tissues, are specialized for the storage of energy in the form of lipid triglycerides. Macrophages are an evolutionarily conserved immune cell population and are the most…

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    • PERSPECTIVE: #FatStorage An anti-obesity #immunotherapy? https://t.co/bJ3kBecHcI @ScienceMagazine #Diet-regulated production of PDGFcc by #macrophages controls energy storage v #fat https://t.co/13LgaqqAuK #PDGF #PDGFcc #brownfat #obesity #Adipocyte

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    Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be highly dynamic organs. Adipose tissues undergo profound changes during development and regeneration and readily undergo remodeling to meet the demands of an everchanging metabolic landscape. The dynamics are determined by the high plasticity of adipose tissues, which contain various cell types: adipocytes,…

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    • Adipose tissue plasticity and the pleiotropic roles of BMP signaling – #JBCReview #BMPs #Adipogenesis #Plasticity #Adipocyte #Macrophage https://t.co/zjgOVYliSN @FudanUniv