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Mashup Score: 0
Bioactive small molecules that form covalent bonds with a target protein are important tools for basic research and can be highly effective drugs. This review highlights reactive groups found in a collection of thiophilic and oxophilic drugs that mediate pharmacological activity through a covalent mechanism of action (MOA). We describe the application of advanced proteomic and bioanalytical…
Categories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Copper-catalyzed electrochemical C–H fluorination - 1 year(s) ago
We report the systematic development of an electrochemical method that translates stoichiometric C–H fluorination reactivity of a copper(III) fluoride complex into a catalytic process. The challenges associated with a highly reactive copper(III) species are addressed by the judicious selection of electrolyte, fluoride source, and sacrificial electron acceptor. The catalyst-controlled C–H…
Source: Chem CatalysisCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1
We developed two molecules based on carbazole and benzotriazole that display brightly emissive properties in both the solution and solid state. The dual-state emission property is facilitated by their twisted structures suppressing the nonradiative pathway caused by deleterious π-π interactions. Moreover, the experimental and theoretical data reveal that high-viscosity media inhibit a…
Source: MatterCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future - 1 year(s) ago
Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain, neurodegeneration, and osteoporosis. A diverse pharmacopoeia of cannabinoid ligands is available, which has led to considerable advancements in…
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Mashup Score: 3
Proton-electron dual conductors with a well-defined structure allow for efficient charge transport while promoting a fundamental understanding of dual conduction. Herein, we present Zn-HHTP-H2O, a proton-electron dual-conducting MOF, which serves as a functionalizable platform. We found that substituting H2O with urea leaves electrical conductivity nearly the same while increasing proton…
Source: ChemCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2
The crystal structure of metal NMs is a crucial factor in determining corresponding physical and chemical properties [1–4], indicating that phase control and investigating new-type crystal structures (not represented by well-known crystal structures) are quite important for developing new functions as well as enhancing well-known properties. For that purpose, NMs are attractive because the phase…
Source: Trends in ChemistryCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Catalysis; Organic synthesis; Organic compound
Source: iScienceCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Cell Press chemistry: Cell Press - 1 year(s) ago
Cell Press is a home for your chemistry research
Source: www.cell.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells - 1 year(s) ago
Mitochondrial cysteine oxidation regulates diverse pathways. Kisty et al. couple proximity labeling with redox proteomics to measure cysteine oxidation on mitochondrial proteins. Basal levels of oxidation on proteins localized in the matrix and intermembrane space are measured using TurboID. Cysteine oxidation within reactive oxygen species hotspots is determined using APEX.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Reticular chemistry for the rational design of mechanically robust mesoporous merged-net metal-organic frameworks - 1 year(s) ago
Mechanical stability plays a key role in the practical applications of metal-organic frameworks (MOFs). This study provides new insight into the design of high-mechanical-stability MOFs by merging two mechanically fragile frameworks into a more robust framework. A mesoporous MOF with high mechanical stability was synthesized by combining the topological merged-net approach and the introduction of…
Source: MatterCategories: General Medicine News, Latest HeadlinesTweet
Check out this review in @Trendsinpharma "Reactive chemistry for covalent probe and therapeutic development" from R. Justin Grams and Ku-Lung Hsu @ChemistryUVA @Hsu_Lab_UVa @GramsJustin #ACSSpring2023 https://t.co/uCPLm57Exz