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    The vast majority of cases of infectious cystitis are easily treated, and most patients have no long-term complications. However, hemorrhagic cystitis is a potentially deadly complication associated with pelvic radiation therapy, chemotherapy, and stem-cell …

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    • Mechanism of hemorrhagic cystitis and prevention. https://t.co/rwJ55dYZTL #cyclophosphamide, #ifosfamide, #acrolein, #mesna #HemeOnc_Topic_Review #HemeOnc_Clinical_Pearls #medtwitter #MedEd

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    Natural antibodies, predominantly immunoglobulin M (IgM), play an important role in the defense against pathogens and in maintaining homeostasis against oxidized molecules known as oxidation-specific epitopes, such as those contained in oxidized low-density lipoproteins. However, owing to the complexity of the oxidized products, very few individual epitopes have been characterized in detail. In…

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    • Endo et al. present results that show the presence of innate B cells expressing the acrolein-specific BCR, and suggest that acrolein may play a role as a trigger of the innate immune response. – #InnateImmunity #Immunology #Acrolein https://t.co/6eDeQZQ4uS @UTokyo_News_en