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Mashup Score: 0ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification - Journal of Biomedical Science - 8 month(s) ago
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases. Besides chronic diseases, ACE2 is the host receptor for SARS-CoV or SARS-CoV-2 virus, mediating the first step of virus infection. ACE2 levels are regulated by transcriptional, post-transcriptional, and post-translational regulation or modification. ACE2 transcription is enhanced by transcription factors including Ikaros, HNFs, GATA6, STAT3 or SIRT1, whereas ACE2 transcription is reduced by the transcription factor Brg1-FoxM1 complex or ERRα. ACE2 levels are also regulated by histone modification or miRNA-induced destabilization. The protein kinase AMPK, CK1α, or MAP4K3 phosphorylates ACE2 protein and induces ACE2 protein levels by decreasing its ubiquitination. The ubiquitination of ACE2 is induced by the E3 ubiquitin ligase MDM2 or UBR4 and decreased by the deubiquitinase UCHL1 or USP50. ACE2 protein levels are also increased by the E3 lig
Source: jbiomedsci.biomedcentral.comCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0
AbstractAims. Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory renin–angiotensin system that is down-regulated during the deve
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Short-circuiting #BloodPressure regulation🔌⚡️ #ANGII upregulation of neural Nedd4-2 promotes #ACE2 ubiquitination to decrease PVN sympathetic inhibition & drive #hypertension https://t.co/sYErpFMeJm @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #CardiovascularResearch #CardioTwitter https://t.co/I9O0s9dMFS
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Mashup Score: 0
Kim et al. uncover how SARS-CoV-2 variants evolve to be more dependent on heparan sulfate in viral attachment and infection. A combination of computational and experimental techniques reveal that increased positive charge on spike proteins leads to enhanced binding to heparan sulfate, informing the design of rapid diagnostics for COVID.
Source: Cell Reports Physical ScienceCategories: Infectious Disease, Latest HeadlinesTweet-
💡 Drs. @RommieAmaro, Ronit Freeman (@RFreeman_Lab), and collaborators investigate the impact of an evolving spike positive charge in SARS-CoV-2 variants on interactions with heparan sulfate and the #ACE2 in the glycocalyx. @UCSanDiego @UNC Learn more: 📑 https://t.co/H3wFcY6U7N https://t.co/ZriiSBBoqz
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Mashup Score: 5Effect of ACE Inhibitor and ARB Initiation on Organ Support–Free Days in Patients With COVID-19 - 1 year(s) ago
This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on the composite outcome of hospital survival and organ support through 21 days in hospitalized patients with COVID-19.
Source: jamanetwork.comCategories: Cardiologists, Latest HeadlinesTweet-
*New* in @JAMA_current #ACE2 is functional receptor of #SARSCoV2. Might #RASi be effective in modifying #COVID19? In @remap_cap RCT led by #PatrickLawler, contrary to our hypothesis: ⚠️Starting #RASi likely worsened outcomes in critically-ill #COVID19 https://t.co/RKmqxurgMV https://t.co/p2DkBj1Brn
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Mashup Score: 1Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein - Critical Care - 2 year(s) ago
Background SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin–angiotensin system (RAS) is involved in the pathogenesis of SARS-CoV-2-induced ALI. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2 and a crucial negative regulator of RAS. Recombinant…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Recombinant #ACE2 plays a protective role against #SARS_CoV_2 lung injury https://t.co/WfbH5mvp0W @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #rACE2 #pandemics #virus #spike_protein https://t.co/IIRovoP94w
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Mashup Score: 2
In this article, Niemi, Daly and Ganna discuss how large-scale genomics studies are providing a rapidly maturing understanding of the influence of host genetics on coronavirus disease 2019 (COVID-19) susceptibility and severity. They also describe the implications for identifying causal mechanisms of pathology and potential therapeutic opportunities.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet-
See also: The human genetic epidemiology of COVID-19 @NatureRevGenet May 2022 https://t.co/p2HfFBbQ25 #GWAS #genetics #race #diversity #DEI #ACE2 https://t.co/gdQ4QRNWhd https://t.co/1bnDMUQc3y
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Mashup Score: 1Genetic Landscape of the ACE2 Coronavirus Receptor - 2 year(s) ago
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, enters human cells using the angiotensin-converting enzyme 2 (ACE2) protein as a receptor. A
Source: CirculationCategories: Cardiologists, Latest HeadlinesTweet-
Genetic Landscape of the ACE2 Coronavirus Receptor In this largest genome-wide association meta-analysis of plasma #ACE2 levels in over 28,000 individuals of the SCALLOP Consortium,ACE2 shares a genetic basis with CVD, COVID19, and other related diseases https://t.co/QKYdwYI7p1 https://t.co/Ng680x5U1G
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Mashup Score: 0Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection - 2 year(s) ago
Background The COVID-19 pandemic continues to be a worldwide threat and effective antiviral drugs and vaccines are being developed in a joint global effort. However, some elderly and immune-compromised populations are unable to raise an effective immune response against traditional vaccines. Aims We hypothesised that passive immunity engineered by the in vivo expression of anti-SARS-CoV-2…
Source: ThoraxCategories: Infectious Disease, Latest HeadlinesTweet-
A single intranasal dose of rAAV9 or rSIV.F/HN vectors expressing anti-SARS-CoV-2 monoclonal antibodies significantly reduced SARS-CoV-2 mimic infection in the lower respiratory tract of human #ACE2-expressing mice. | By @RDMOxford scientists. https://t.co/rmJgXZXrTi https://t.co/lu0qR5Yv0Y
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Mashup Score: 5ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury - Nature Communications - 2 year(s) ago
Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.
Source: Nature CommunicationsCategories: Infectious Disease, Latest HeadlinesTweet-
New in @NatureComms! Researchers from Akita University have shown that increasing #ACE2-like enzymatic activity is a potential therapeutic strategy to alleviate lung pathologies in #COVID19 patients. https://t.co/qa7nbXyIUH https://t.co/f0OOPAcJ9M
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Mashup Score: 0Meet the winner of the first annual Desmond Julian Award - 2 year(s) ago
All correspondence relating to this paper should be sent to cardiopulse@unicatt.it
Source: OUP AcademicCategories: Cardiologists, Latest HeadlinesTweet-
We are pleased to announce the first winner of the Desmond Julian award for an outstanding paper published in the EHJ. Dr Iziah Sama from University Medical Center Groningen. #EHJ #COVID-19 #ACE2 https://t.co/kWscwpWhmf https://t.co/sKyUFiSIu8
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💬 Let's talk about #ACE2 in chronic disease and #COVID19! Understanding the regulation and modification of ACE2 may help to develop prevention or treatment strategies for ACE2-mediated diseases. 🔖 Don't forget to bookmark and share! 📖 #review | https://t.co/UvR8z2IWiW https://t.co/MQ7UtAU0Zf