T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage

As the intestinal epithelium is replaced every week, maintenance of this tissue requires rapid self-renewal that is driven by intestinal stem cells. This homeostasis is disrupted in a number of settings, including allogeneic bone marrow transplantation. After allogeneic bone marrow transplantation, allogeneic T cells often attack and kill intestinal cells in an interferon-γ (IFNγ)–dependent…

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