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Mashup Score: 4The Coagulopathy of Acute Promyelocytic Leukemia: An Updated Review of Pathophysiology, Risk Stratification, and Clinical Management - 1 year(s) ago
Acute promyelocytic leukemia (APL) has a well-established mechanism and a long-term prognosis that exceeds that of any other acute leukemia. These improving outcomes are due, in part, to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), two targeted and highly active agents in this disease. However, there remains a considerable morbidity and mortality risk in APL secondary to clinically…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Since their discovery at the beginning of this millennium, glioma stem cells (GSCs) have sparked extensive research and an energetic scientific debate about their contribution to glioblastoma (GBM) initiation, progression, relapse, and resistance. Different molecular subtypes of GBM coexist within the same tumor, and they display differential sensitivity to chemotherapy. GSCs contribute to tumor…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5
The dynamic processes operating on genomic DNA, such as gene expression and cellular division, lead inexorably to topological challenges in the form of entanglements, catenanes, knots, “bubbles”, R-loops, and other outcomes of supercoiling and helical disruption. The resolution of toxic topological stress is the function attributed to DNA topoisomerases. A prominent example is the negative…
Source: MDPICategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0Soy-Based Tempeh Rich in Paraprobiotics Properties as Functional Sports Food: More Than a Protein Source - 1 year(s) ago
To date, there has been no recent opinion that explores tempeh as a functional food that can improve sports performance. Hence, this opinion article aims to elaborate on recent findings on the potential effect on sports performance of soy-based tempeh. This opinion paper presents updated evidence based on literature reviews about soy-based tempeh and its relationship with sports performance. The…
Source: MDPICategories: Latest Headlines, Partners & KOLsTweet
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Mashup Score: 0Use of Ethanol Injections to Create a Complete Atrioventricular Block in a Rat Model - 1 year(s) ago
Complete atrioventricular block (AVB) is an abnormal heart rhythm resulting from a defect in the cardiac conduction system. Patients with complete AVB are at risk of symptoms ranging from syncope or hypotension to cardiovascular collapse or sudden cardiac death. A reliable animal model of complete AVB is essential for understanding the mechanisms underlying the fatal hemodynamic effects and…
Source: MDPICategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Expert Consensus: Main Risk Factors for Poor Prognosis in COVID-19 and the Implications for Targeted Measures against SARS-CoV-2 - 1 year(s) ago
The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The evolution to less aggressive but better-transmitted viral variants, and the presence of immune memory responses in a growing number of vaccinated and/or virus-exposed individuals, has caused the pandemic to slowly wane…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 19A Practical Guide for the Management of Steroid Induced Hyperglycaemia in the Hospital - 1 year(s) ago
Glucocorticoids represent frequently recommended and often indispensable immunosuppressant and anti-inflammatory agents prescribed in various medical conditions. Despite their proven efficacy, glucocorticoids bear a wide variety of side effects among which steroid induced hyperglycaemia (SIHG) is among the most important ones. SIHG, potentially causes new-onset hyperglycaemia or exacerbation of…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Two Different Heated Tobacco Products vs. Cigarettes: Comparison of Nicotine Delivery and Subjective Effects in Experienced Users - 1 year(s) ago
Heated tobacco products (HTPs) produce aerosol using a different mechanism than tobacco cigarettes, leading to lower emissions of some harmful substances, but also of nicotine as reported by some independent studies. Lower nicotine delivery could lead to compensatory puffing when product use does not sufficiently satisfy cravings. Thus, this three-arm crossover study was conducted to characterize…
Source: MDPICategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 3HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B - 1 year(s) ago
Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B genome in every cell, are referred to as having inherited chromosomally-integrated…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 16Coarctation of the Aorta: Diagnosis and Management - 1 year(s) ago
Coarctation of the aorta (CoA) accounts for approximately 5–8% of all congenital heart defects. Depending on the severity of the CoA and the presence of associated cardiac lesions, the clinical presentation and age vary. Developments in diagnosis and management have improved outcomes in this patient population. Even after timely repair, it is important to regularly screen for hypertension….
Source: MDPICategories: Cardiologists, Latest HeadlinesTweet
The Coagulopathy of Acute Promyelocytic Leukemia: An Updated Review of Pathophysiology, Risk Stratification, and Clinical Management https://t.co/EPWcELFprI #mdpicancers via @Cancers_MDPI #AML #leusm https://t.co/6wjJmE8CYy