VCAM-1-targeted magnetic resonance imaging improves detection of the tumor-brain interface

Abstract. Purpose: Despite optimal local therapy, tumor cell invasion into normal brain parenchyma frequently results in recurrence in patients with solid tumors. The aim of this study was to determine whether microvascular inflammation can be targeted to better delineate the tumor-brain interface through vascular cell adhesion molecule-1 (VCAM-1)-targeted magnetic resonance imaging (MRI)….

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