Staphylococcus aureus, a human opportunist pathogen, adjusts its metabolism to cope with iron deprivation within the host. We investigated the potential role of small non-coding RNAs (sRNAs) in dictating this process. A single sRNA, named here IsrR, emerged from a competition assay with tagged-mutant libraries as being required during iron starvation. IsrR is iron-repressed and predicted to…
Genomic sequencing’s adoption in public health laboratories (PHLs) for pathogen surveillance is innovative yet challenging, particularly in the realm of bioinformatics. Low- and middle-income countries…
The tree of blobs of a species network shows only the tree-like aspects of relationships of taxa on a network, omitting information on network substructures…
Combinatorial control by multiple transcription factors (TFs) allows for increased specificity and information integration. Despite its prevalence in eukaryotes and crucial roles in gene regulation,…
A key aim in the dynamics and control of infectious diseases is predicting competitive outcomes of pathogen interactions. Observed pathogen community structure indicates both considerable…
Giant viruses significantly regulate the ecological dynamics of diverse ecosystems. Although metagenomics has expanded our understanding of their diversity and ecological roles played in marine…
A critical function of central neural circuits is to integrate sensory and internal information to cause a behavioural output. Evolution modifies such circuits to generate…
Epilepsy is a common neurological condition that arises from dysfunctional neuronal circuit control due to either acquired or innate disorders. Autophagy is an essential neuronal…
Primate lateral intraparietal area (LIP) is critical for cognitive processing. Its contribution to categorization and decision-making has been causally linked to neurons’ spatial sensorimotor selectivity.…
Fluctuations in oscillatory brain activity have been shown to co-occur with variations in task performance. More recently, part of these fluctuations has been attributed to…
The Single-cell Pediatric Cancer Atlas (ScPCA) Portal (https://scpca.alexslemonade.org/) is a data resource for uniformly processed single-cell and single-nuclei RNA sequencing (RNA-seq) data and de-identified metadata…
