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Environmentally dependent and independent control of 3D cell shape
Using high-throughput light-sheet microscopy, Dent et al. study 3D cancer cell morphogenesis. Environmental cues modulate the opposing roles of non-muscle myosin II (myosin) and microtubules, with…
SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell…
Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval
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Shocking Study Reveals Many Fast-Tracked Cancer Drugs Offer No Clinical Benefit
This is not what we wanted to see.
Drug shortages reach record high in US | CNN
There are more active drug shortages in the United States than ever, according to data from the American Society of Health-System Pharmacists and the University of…
Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval
This study aims to determine whether cancer drugs granted accelerated approval from the US Food and Drug Administration ultimately demonstrate clinical benefit and to evaluate…