eLife collaborates with Novel Coronavirus Research Compendium on manuscript curation and review
The two initiatives have come together in their shared objective to help scientists and the public navigate the high volume of important new research.
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Abstract Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities…
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.
Suppression of transcytosis regulates zebrafish blood-brain barrier function
The zebrafish has been established as a genetic and molecular model for the blood-brain barrier.
Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain
A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
Ebola virus disease in the Democratic Republic of the Congo, 1976-2014
Analysing a compilation of individual-level data gathered across the seven Ebola Virus Disease outbreaks in the Democratic Republic of the Congo reveals factors that contribute…
Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial
A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one’s genetics and physiology increases its placebo effect on pain.
Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma
Abstract Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the…
Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein
A human endogenous fusogen, syncytin, which facilitates placental cell-cell fusion during early embryonic development, mediates the formation of open-ended membrane tubular connections between other cell…
Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma
Abstract Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the…
Epidemiological characteristics and prevalence rates of research reproducibility across disciplines: a scoping review of articles published in 2018-2019
Abstract Introduction: Reproducibility is a central tenant of research. We aimed to synthesize the literature on reproducibility and describe its epidemiological characteristics, including how reproducibility…
