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BACKGROUND: Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of inflammation...

BACKGROUND: Cross-talk between sterol metabolism and inflammatory pathways has been demonstrated to significantly affect the development of atherosclerosis. Cholesterol biosynthetic intermediates...

Background: VERVE-101 is an investigational in vivo CRISPR base editing medicine designed to alter a single DNA base in the PCSK9 gene, permanently turn...

BACKGROUND: Autoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional features of cardiac autoimmunity in humans remain undefined...

Approximately 2 years ago, the American Heart Association’s (AHA) National Board commissioned volunteer leaders to develop new goals to address health equity and to...

Philippe Gabriel Steg * Corresponding Author; email: E-mail Address: [email protected] https://orcid.org/0000-0001-6896-2941 Université Paris-Cité, Paris, France ; Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France...

The technological evolution and widespread availability of wearables and handheld ECG devices capable of screening for atrial fibrillation (AF), and their promotion directly to...

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    “Companies marketing #AFib screening devices should report the accuracy & performance of their products in high- & low-risk populations & avoid claims about clinical outcomes unless improvement is demonstrated in RCTs.” ⁦⁦⁦⁦⁦@CircAHAhttps://t.co/2r4pVrkXC6 - view on twitter

Background: Identifying genetic variants which impact the level of cell cycle reentry and establishing the degree of cell cycle progression in those variants could...

BACKGROUND: Pulmonary hypertension (PH) is associated with increased expression of VEGF-A (vascular endothelial growth factor A) and its receptor, VEGFR2 (vascular endothelial growth factor...

The technological evolution and widespread availability of wearables and handheld ECG devices capable of screening for atrial fibrillation (AF), and their promotion directly to...