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Cell Host & Microbe

Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner - 2 weeks

Mashup Score:246

Keeton, Richardson, Moyo-Gwete et al show that SARS-CoV-2 infection prior to Ad26CoV2.S vaccination significantly boosts cross-reactive ADCC, binding and neutralizing antibodies, and moderately boosts...

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Mashup Score:1

Cell Host & Microbe

Prophages encode phage-defense systems with cognate self-immunity - 3 weeks

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Prophages can encode abortive infection proteins that give their bacterial hosts population-level phage defense. Owen et al. show that some of these proteins contain internal...

More coverage: #bacteria
See more from Immunology of Infectious Disease News

Mashup Score:34

Cell Host & Microbe

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1 - 2 months

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Li and Hang et al. identify a biosynthetic pathway by which abundant human gut bacterial species from the phylum Bacteroidetes convert the secondary bile acid...

More coverage: #gastroedpick #gutmicrobiome
See more from Nature Reviews Gastroenterology & Hepatology

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Cell Host & Microbe

An AAV-based, room-temperature stable, single dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates - 3 months

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Zabaleta and colleagues report AAVCOVID, an experimental preventative vaccine for COVID-19. AAVCOVID is a vaccine that delivers the SARS-CoV-2 Spike antigen as a gene...

More coverage: #immunogenicity #injection #sars
See more from Immunology of Infectious Disease News

Mashup Score:2

Cell Host & Microbe

Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice - 3 months

Mashup Score:2

Using a mouse model in which early-life antibiotics enhance T1D, Zhang et al. show that subsequent maternal cecal microbiota transfer reduces illness. The restorative effects...

See more from Marcel van den Brink

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Cell Host & Microbe

Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir - 3 months

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Rajashekar et al. show that a small molecule CD4 mimetic, in concert with non-neutralizing antibodies, decreases the size of HIV-1 reservoir in new generation humanized...

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Mashup Score:318

Cell Host & Microbe

SnapShot: SARS-CoV-2 antibodies - 3 months

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Monoclonal antibody therapies hold great promise for COVID-19; however, the recent emergence and spread of escape variants threaten to limit their value. Shown here...

More coverage: #sarscov2
See more from Eric Topol
Cell Host & Microbe

HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens - 3 months

Mankind is currently struggling with two pandemics driven by RNA viruses, HIV-1 and SARS-CoV-2. Here we compare how evolutionary strategies for diversification manifest in...

See more from David A. Russler-Germain

Mashup Score:13

Cell Host & Microbe

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity - 4 months

Mashup Score:13

Motozono and G2P-Japan Consortium et al. show that the emerging mutations L452R and Y453F in the SARS-CoV-2 spike receptor-binding motif evade HLA-A24-restricted cellular immunity. L452R...

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Mashup Score:15

Cell Host & Microbe

TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma - 4 months

Mashup Score:15

CD4 T cell function at the site of infection is crucial to control Mycobacterium tuberculosis. Gern, Adams et al. show that TGFβ inhibits CD4 T cell function...

More coverage: #isscr2021
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