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Cancer Cell

Challenges and opportunities for modeling aging and cancer - 2 hours

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Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet,...

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Cancer Cell

A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade - 7 hours

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Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely...

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Cancer Cell

Challenges and opportunities for modeling aging and cancer - 11 hours

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Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet,...

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Cancer Cell

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma - 24 hours

Transcriptional changes between primary and recurrent IDH-wt glioblastomas are largely unexplored since resections on recurrent glioblastoma are scarce. Hoogstrate et al. show that longitudinal glioblastoma...

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Cancer Cell

Disputed Paternity: The Uncertain Ancestry of Pancreatic Ductal Neoplasia - 1 day

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In this issue of Cancer Cell, Kopp and colleagues report that pancreatic ductal cells are largely refractory to the induction of pancreatic neoplasia. Whereas...

  • 1641247458826104832 Profile photo of Madelyn
    Anirban Maitra

    Steve Leach and I wrote about some of these issues over a decade ago. Technology has come a long way since, allowing unbiased profiling of the “epigenetic determinants” we allude to in the last paragraph in limited microdissected human biospecimens. https://t.co/HSfBGMsWk2 - view on twitter

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Mashup Score:13

Cancer Cell

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth - 3 days

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de Visser and Joyce review the complex interplay between the tumor and its microenvironment throughout cancer evolution and discuss the tumor cell-intrinsic, cell-extrinsic, and...

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Cancer Cell

Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma - 6 days

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Massive MDSC infiltration, pro-tumor TAM polarization, and angiogenesis in glioma constitute barriers to counteract ICB-elicited antitumor immunity. Liu et al. show that IL-8, derived from...

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Cancer Cell

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis - 1 week

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Modulating the tumor immune microenvironment in a molecularly defined manner remains a major challenge. Zhou et al report a molecular mechanism of ARID1A regulated immuno-stimulatory...

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Cancer Cell

Epithelial cells activate fibroblasts to promote esophageal cancer development - 1 week

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Chen et al. perform single-cell and spatial transcriptomic analyses of multistage esophageal lesions and reveal gradual loss of ANXA1 expression in epithelial cells during ESCC...

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Mashup Score:75

Cancer Cell

Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade - 1 week

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Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with...

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