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The anti-mycobacterial activity of Artemisia annua L is based on deoxyartemisinin and artemisinic acid

posted 10 hours

Mashup Score: 4

bioRxiv - The discovery of antimalarial artemisinin from Artemisia annua L. is an example of how Traditional Chinese Medicine (TCM) may be exploited to meet a...

bioRxiv - Astronauts exhibit an assortment of clinical abnormalities in their eyes during long-duration spaceflight. The purpose of this study was to determine whether spaceflight induces...

  • Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina https://t.co/2DLaMiifph #bioRxiv

Neural networks to learn protein sequence-function relationships from deep mutational scanning data

posted 3 hours

Mashup Score: 3

bioRxiv - The mapping from protein sequence to function is highly complex, making it challenging to predict how sequence changes will affect a protein’s behavior and...

bioRxiv - There is growing evidence that humans use olfactory chemosensory signals for social communication, but their role in affective associative learning is largely unknown. To...

  • Women show enhanced attractiveness ratings and neural processing of male faces associated with male chemosensory signals https://t.co/Fs6lVCrt3j #bioRxiv

Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF, and AGT

posted 1 day

Mashup Score: 3

bioRxiv - Excessive inflammatory signaling and pathological remodeling of the extracellular matrix are important contributors to cardiac fibrosis and involve major changes in gene expression. We...

bioRxiv - We have developed a generally applicable method based on CRISPR/Cas9-targeted ultra-long read sequencing (CTLR-Seq) to completely and haplotype-specifically resolve, at base-pair resolution, large, complex,...

  • Complete and haplotype-specific sequence assembly of segmental duplication-mediated genome rearrangements using targeted CRISPR-targeted ultra-long read sequencing (CTLR-Seq) https://t.co/6qQPx3XKi6 #bioRxiv

bioRxiv - Using atomistic molecular dynamics simulations, we study the interaction of ternary methacrylate polymers, composed of charged cationic, hydrophobic and neutral polar groups, with model...

  • Towards designing globular antimicrobial peptide mimics: role of polar functional groups in biomimetic ternary antimicrobial polymers https://t.co/OKJjrmgtBM #bioRxiv

MicroRNA840 accelerates leaf senescence by targeting the overlapping 3’UTRs of PPR and WHIRLY3 in Arabidopsis

posted 23 hours

Mashup Score: 2

bioRxiv - MicroRNAs (miRNAs) negatively regulate gene expression by cleaving the target mRNA and/or impairing its translation, thereby playing a crucial role in plant development and...

De novo design of transmembrane beta-barrels

posted 2 days

Mashup Score: 2

bioRxiv - Transmembrane β-barrel proteins (TMBs) are of great interest for single-molecule analytical technologies since they can spontaneously fold and insert into membranes and form stable...

Alignment-free methods for polyploid genomes: quick and reliable genetic distance estimation

posted 10 hours

Mashup Score: 2

bioRxiv - Polyploid genomes pose several inherent challenges to population genetic analyses. While alignment-based methods are fundamentally limited in their applicability to polyploids, alignment-free methods bypass...