The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis
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bioRxiv - RIPK3 amyloid complex plays crucial roles in execution of TNF-induced necroptosis and in response to immune defense in both human and mouse. We have...
Reference data based insights expand understanding of human metabolomes
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bioRxiv - The human metabolome has remained largely unknown, with most studies annotating ~10% of features. In nucleic acid sequencing, annotating transcripts by source has proven...
bioRxiv - Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain dopaminergic neurons (DAN). Non-human primates (NHPs) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed...
DIET INFLUENCES PERIPHERAL AMYLOID BETA METABOLISM: A ROLE FOR CIRCULATING INSULIN-LIKE GROWTH FACTOR I
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bioRxiv - Obesity is a risk factor for Alzheimer disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid-beta (Abeta) in overweight...
Loss of Cdk5rap2 triggers cellular senescence via β-catenin-mediated downregulation of WIP1
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bioRxiv - Loss-of-function mutations in Cdk5rap2 is associated with the developmental disorders, primary microcephaly and primordial dwarfism, but the underlying molecular link remains obscure. Here, we...
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
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bioRxiv - SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific...
The Phylogenomics of CRISPR-Cas System in Salmonella: an evolutionary race with housekeeping genes
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bioRxiv - Salmonellae display intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition/exchange of various virulence factors influence the evolutionary framework. To...
Genome-wide macroevolutionary signatures of key innovations in butterflies colonizing new host plants
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bioRxiv - The exuberant proliferation of herbivorous insects is attributed to their associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether...
bioRxiv - In species with polygenic sex determination, multiple male- and/or female-determining loci on different proto-sex chromosomes segregate as polymorphisms within populations. The extent to which...
A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate
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bioRxiv - The explosively expanding COVID-19 pandemic urges the development of safe, efficacious and fast-acting vaccines to quench the unrestrained spread of SARS-CoV-2. Several promising vaccine...
The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis https://t.co/dgdgtmqHcn #bioRxiv