Severe hypoxemia in some patients with coronavirus disease (COVID-19) has been related to loss of hypoxic pulmonary vasoconstriction (1, 2). A 77-year-old male with 6 days of mild respiratory symptoms and no comorbidities was admitted with signs of respiratory failure (PaO2/FiO2: 61 mm Hg/0.36 mm Hg = 169.4 mm Hg; reference values…
The 17q12–21 region harboring the candidate asthma genes ORMDL3 and GSDMB is the most important and consistently replicated asthma susceptibility locus. The region is strongly…
“.” American Journal of Respiratory Cell and Molecular Biology, 70(4), pp. 322–325 Supported by National Institutes of Health grants R01 AT011676 (X.S.), 1R01 HL160019-01 (X.S.),…
Mammalian lungs are directly exposed to environmental pathogens and toxins and have evolved complex defense mechanisms, including the mucociliary escalator and secretion of antimicrobial peptides…
“.” Annals of the American Thoracic Society, 21(4), pp. 663–668 Correspondence and requests for reprints should be addressed to Andrew M. Luks, M.D., Division of…
“.” American Journal of Respiratory and Critical Care Medicine, 209(7), pp. 879–880 Supported by the National Natural Science Foundation of China (grant 81900021), Beijing Clinical…
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease caused by an aberrant repair of injured alveolar epithelial cells. The maintenance of the alveolar…
There is considerable interest in the potential for cell-based therapies, particularly mesenchymal stromal cells (MSCs) and their products, as a therapy for acute respiratory distress…
Ventilator-induced lung injury (VILI) is a potential threat to anyone receiving supportive mechanical ventilation for acute respiratory failure. Despite decades of research, however, the safest…
Rationale: Patients identified as Hispanic, the largest minority group in the United States, are more likely to die from acute respiratory distress syndrome (ARDS) than…
Alveolar type 2 (AT2) cells are progenitors of alveolar type I cells and play a critical role in the regeneration of the alveoli after injury.…
