Lung and bladder cancers are difficult to treat because of the development of drug-refractory metastases. Chrysostomou et al. show that the p90 ribosomal protein S6 kinase 4 (RSK4) is involved in the development of chemotherapy resistance and metastatic invasion in both in vitro and in vivo models. Identification of a binding site for floxacin antibiotics on RSK4 led to the finding that…
To understand vulnerable glaciers, climate scientists extract ice from continent’s remote and stormy coast
The pursuit of artificial general intelligence (AGI) continuously demands higher computing performance. Despite the superior processing speed and efficiency of integrated photonic circuits, their capacity…
A novelist’s venture into nonfiction is filled with deep insights about life on Earth but may leave some wanting more
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Jupiter’s moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io’s inventory of volatile chemical elements, including sulfur and chlorine, reflects…
COVER Humanity’s actions have committed us to a warming climate and limited our options for mitigation. Although there is no turning back, some paths are…
Remote sensing tools provide the big picture often missing from on-the-ground studies
“In the end, I found the courage to ask questions in front of large audiences,” this researcher writes
Grasp analysis, motion plans, and field tests are presented for a robot using extendable booms to navigate difficult terrain.
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but…
