Renal denervation – radiofrequency vs. ultrasound: insights … : Journal of Hypertension
(rRDN) and ultrasound RDN (uRDN), when compared with sham in patients with hypertension. Methods: PubMed, EMBASE, and clinicaltrials.gov databases were searched for randomized sham-controlled trials (RCTs) of rRDN or uRDN or for trials of rRDN vs. uRDN. Primary efficacy outcome was 24-h ambulatory SBP. A mixed treatment comparison meta-analysis was performed comparing the efficacy and safety against sham and against each other. Results: Among 13 RCTs that enrolled 2285 hypertensive patients, rRDN reduced 24-h ambulatory SBP [(MD = 2.34 mmHg; 95% confidence interval (95% CI): 0.72–3.95], office SBP (MD = 5.04 mmHg; 95% CI: 2.68–7.40)], and office DBP (MD = 2.95 mmHg; 95% CI: 1.68–4.22) when compared with sham. Similarly, uRDN reduced 24-h ambulatory SBP (MD = 4.74 mmHg; 95% CI: 2.80–6.67), day-time ambulatory SBP (MD = 5.40 mmHg; 95% CI: 3.68–7.13), night-time ambulatory SBP (MD = 3.84 mmHg; 95% CI: 0.02–7.67), and office SBP (3.98 mmHg; 95% CI: 0.78–7.19) when compared with sham. There
