Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy
Competition among JAKs for receptor binding may underlie cell type–specific differences in cytokine signaling.
Related Articles
SSRI Antidepressants May Cause Fewer Side Effects When Targeted to the Gut
Results identify intestinal epithelial 5-HT as a new and potentially safer therapeutic target for mood regulation.
Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries
Longitudinal patient registries generate important evidence for advancing clinical care and the regulatory evaluation of health-care products. Most national registries rely on data collected as…
Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention
A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who…
Science’s ‘Dance Your Ph.D.’ contest is open again!
This year’s competition has a special category on artificial intelligence research or quantum science—no Ph.D. needed
‘It felt very icky’: This scientist’s name was used to write fake peer reviews
Elsevier retracts dozens of journal articles that were published based on “fictitious” reviews
Imperfect wound healing sets the stage for chronic diseases
Although the age of the genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise…
Dino droppings reveal how the giant beasts came to dominate Earth
Most comprehensive study yet of dinos’ poop and vomit traces their rise in Poland
Scientists fear big cuts to animal research under Trump 2.0
New political environment could provide opening for groups that want to eliminate animal studies
Science and America’s challenge
Today, more than at any time since World War II, the United States is being challenged scientifically on the global stage. Unfortunately, the nation is…
NSF panel says proposed giant telescopes would swamp agency’s budget
TMT and GMT projects remain in limbo after review panel leaves final choice to NSF leadership