Coronavirus disease 2019 (COVID-19) infection results in both acute mortality and persistent and/or recurrent disease in patients with hematologic malignancies, but the drivers of persistent infection in this population are unknown. We found that B-cell lymphomas were at particularly high risk for persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity. Further analysis…
Summary:. Biological characteristics of tumors are heterogeneous, forming spectra in terms of several factors such as age at onset, anatomic spatial localization, tumor subtyping, and…
Summary:. The success of checkpoint blockade cancer immunotherapies has unequivocally confirmed the critical role of T cells in cancer immunity and boosted the development of…
Summary:. Revolutionary advancements in oncology have transformed lives, but the clinical trials ecosystem encounters challenges, including restricted access to innovative therapies and a lack of…
Read the paper: https://doi.org/10.1158/2159-8290.CD-24-0066
In collaboration with several organizations, the College of American Pathologists (CAP) has released recommendations for testing of immunotherapy biomarkers, including PD-L1 and tumor mutation burden,…
Cancer and neuroscience, long regarded as separate fields, have more in common than previously thought. Researchers straddling both worlds to work in cancer neuroscience, an…
Interplay between macrophages and pancreatic cancer cells seems to promote cachexia, researchers reported (Cancer Cell 2024 Apr 11 [Epub ahead of print]). The crosstalk between…
Summary:. Traditional endpoints such as progression-free survival and overall survival do not fully capture the pharmacologic and pharmacodynamic effects of a therapeutic intervention. Incorporating mechanism-driven…
Summary:. An increased understanding of the role of the social determinants of health in cancer prevention, cancer care, and outcomes can lead to their integration…
Summary:. Here, we define a future of cancer team science adopting “radical collaboration”—in which six “Hallmarks of Cancer Collaboration” are utilized to propel cancer teams…
