A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months. Serum neutralizing antibody (nAb) responses waned rapidly but spike (S)-specific IgG+ memory B…
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Allogeneic CAR-DNTs with minimal genetic modification show potent anti-tumor activity without off-tumor toxicities.
Spatially resolved profiling of the melanoma microenvironment reveals correlates of response to immune checkpoint inhibitors.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
ONLINE COVER Cultivating Memory B Cell Responses to a Plant-Based Vaccine. CoVLP (coronavirus virus-like particle) is a promising COVID-19 vaccine produced in the weed Nicotiana…
