‘Polygenic’ analyses may sharpen disease risk predictions

![][1] A woman’s genetic background can powerfully modify her cancer risk from a BRCA1 mutation. PHOTO: VOISIN/SCIENCE SOURCE Women who learn that they have a mutation in the breast cancer gene BRCA1 face a wrenching decision. Their doctor or genetic counselor will likely tell them that women with such mutations have, on average, a 72% lifetime risk of breast cancer and a 44%…

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