Peptidic catalysts for macrocycle synthesis
Many structurally simplified catalysts have been synthesized that mimic the reactivity and efficiency of enzymes. In this context, the numerous transformations catalyzed by the amino acid proline as a catalytic-site mimic helped drive the field of organocatalysis ([ 1 ][1]). Enzyme activity not only relies on the reactive site but also on the structure of the binding pocket that can orient and…