Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway

CARD11 is a critical player in adaptive immunity through its role in intracellular NF-κB signaling upon antigen detection by T or B cells. CARD11 mutations are associated with different immunodeficiencies that are linked to abnormal NF-κB activation, and now Wei et al. have characterized other CARD11 mutations that affect the AKT-FOXO1 signal axis. Using three different mouse models that mimic…

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