Outer Radial Glia–Like Cells May Promote Glioblastoma Invasiveness
Outer radial glia (oRG)–like glioma stem cells (GSC) were enriched in human glioblastomas.
Related Articles
TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Abstract. Immunotherapies against brain metastases have shown clinical benefits when applied to asymptomatic patients, but they are largely ineffective in symptomatic cases for unknown reasons.…
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Machine learning models were trained to identify mutations driving clonal hematopoiesis, demonstrating the potential of data-driven approaches to support the identification of clonal hematopoiesis cases…
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
MYC induces a previously uncharacterized type of oncogenic stress by increasing global RNA degradation and downstream ribonucleotide catabolism and ROS accumulation; this catabolic vulnerability can…
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma
The chromatin remodeler CHD2 regulates neuron–glioma interactions and is a potential therapeutic target for H3.1K27M diffuse midline glioma.
Immune Checkpoint Inhibitors Potentially Curative for Melanoma
Ten-year follow up from the CheckMate 067 and KEYNOTE-006 trials confirm that patients with advanced melanoma can achieve durable responses from treatment with the PD1…
Genentech Buys Regor’s CDK Inhibitors for $850 Million
Genentech acquired Cambridge, MA-based Regor Therapeutics Group’s portfolio of CDK inhibitors for $850 million in cash. The most promising drug candidate included in the deal…
Massive Lawsuit Against BMS Dismissed
A $6.4 billion lawsuit against Bristol Myers Squibb (BMS) was dismissed on Monday. The suit alleged that BMS purposely delayed approval of drugs developed by…
A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution
Integration of epigenetic perturbations of cis-regulatory elements and their genetic profiling in matched relapsed patient cohort revealed the contribution of the noncoding genome to breast…
A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation
A phase I trial with an alternative, pharmacokinetics-informed dose escalation design demonstrated that a brain-penetrant, selective, pan-mutant BRAF inhibitor could overcome resistance to approved BRAF…
Alerts | American Association for Cancer Research
Alerts | American Association for Cancer Research .main-content h1 { font-weight: 300; color: #44b13e; margin-bottom: 0; } .main-content h3 { margin-bottom: 16px; } .main-content h3…