Omics versus Questionnaires: Using methylation data to assess the environmental impact of smoking on obesity-related traits

Variation in complex traits related to obesity, such as body weight and body mass index, has a genetic basis with heritabilities between 40 and 70%. Nonetheless, the so-called global obesity pandemic is usually associated with environmental changes related to diet, lifestyle, and sociocultural and socioeconomic changes. However, most genetic studies do not include all relevant environmental…

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