Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer | NEJM
Original Article from The New England Journal of Medicine — Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer
Original Article from The New England Journal of Medicine — Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer
A 44-year-old man presented with a 5-year history of heat intolerance and burning pain in his hands and feet. He had periumbilical angiokeratomas and nonnephrotic…
Pragmatic and cluster RCTs offer opportunities for advancing research but present ethical challenges. Addressing these challenges requires multidisciplinary expertise and meaningful collaboration.
The addition of zolbetuximab, an anti–claudin 18.2 antibody, to chemotherapy in gastric and gastroesophageal junction adenocarcinoma led to longer progression-free and overall survival than chemoth…
CNS vasculitis exists in medium- and large-vessel, small-vessel, and amyloid-deposition forms. Diagnosis is difficult, but the typical symptoms include acute focal deficits, cognitive impairment, a…
Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive telangiectasias and arteriovenous malformations. The primary clinical manifestation is epistaxis that results in iron-defic…
Chronic graft-versus-host disease (GVHD) remains a rare and unacceptably debilitating autoimmune-like syndrome that afflicts patients in whom a blood disorder or cancer is otherwise cured…
Colony-stimulating factor 1 receptor (CSF1R)–dependent monocytes and macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long-term complication of allogeneic hematopo…
Evidence-based practices for reducing opioid-related overdose deaths include overdose education and naloxone distribution, the use of medications for the treatment of opioid use disorder, and…
Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term…
In a pilot program in which 109,259 newborns were screened for metachromatic leukodystrophy, blood-spot samples were obtained for analysis and three newborns with MLD were…