New therapeutic strategy for chemotherapy resistance in ovarian cancer — SCIENMAG
Cancer stem cell-like cells that emerge after platinum-based therapy and cause relapse can be eliminated by targeting an enzyme in the NAD+ metabolic pathway.Credit: The Wistar Institute PHILADELPHIA — (Dec. 19, 2019) — A study from The Wistar Institute demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following…