Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects – Nature Reviews Nephrology

Novel non-steroidal mineralocorticoid receptor antagonists have a better safety profile than steroidal formulations. This Review examines the pro-inflammatory and profibrotic activity of mineralocorticoid receptor activation and discusses the therapeutic potential of MRAs in the treatment of diabetic kidney disease to improve kidney and cardiovascular outcomes.

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