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Mashup Score: 6Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques - 1 year(s) ago
Administration of a mutated IFN-α2 to rhesus macaques limited viral replication and pathogenesis during SARS-CoV-2 infection.
Source: www.science.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques - Nature Communications - 2 year(s) ago
Although antiretroviral therapy (ART) is able to successfully suppress plasma viremia in most people living with HIV, ART withdrawal typically results in viral replication and rebound. Authors investigate the effect, in terms of delay in viral replication, and immune cell dynamics in lymphoid tissue, of fingolimod (FTY720) administration at the time of ART initiation in SIV-infected rhesus…
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet-
📍 New research out of the @PaiardiniLab at @EmoryUniversity demonstrates the limited impact of #fingolimod treatment during the initial weeks of antiretroviral therapy in #SIV-infected rhesus macaques. Full article in @NatureComms: 📎 https://t.co/0AdSclhWd4 https://t.co/D95LJxnHtu
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Mashup Score: 10Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques - 4 year(s) ago
Using a rhesus macaque infection model, it is shown that baricitinib treatment started early after infection effectively resolves inflammatory signatures in airway macrophages, with decreased lung pathology and neutrophil infiltration.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A rhesus macaque #infection model shows that #baricitinib treatment soon after #SARSCoV2 infection resolves #inflammatory signatures in airway #macrophages. Out now! https://t.co/1mBv2xrD5j @PaiardiniLab @EmoryUniversity @CellCellPress #coronavirus hub - https://t.co/BCdU2ltXnp https://t.co/0zt09yvzgJ
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Mashup Score: 0Please wait whilst we redirect you - 4 year(s) ago
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Source: www.sciencedirect.comCategories: Cardiologists, Latest HeadlinesTweet-
When I started studying neutrophils in 2014, I never thought they would be key to understanding and treating #COVID19. Grateful to @PaiardiniLab @BosingerLab and @drugbuster21 for this wonderful collaboration. @EmoryDeptofMed @emoryheart @Michael_Saying https://t.co/qjJS6KmkyR
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New primate research by @elise_viox and colleagues from @BosingerLab and @PaiardiniLab corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. https://t.co/O4dH2AKvkR https://t.co/wp4lUa5Uyf