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Mashup Score: 10Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis - Nature Communications - 1 year(s) ago
Although remodelling of the extracellular matrix (ECM) is associated with the establishment of an immunosuppressive tumour microenvironment, whether the ECM can educate tumor-associated macrophage phenotypes is not known. Here, the authors examine this question using decellularized tissue models of omental metastasis from patient biopsies.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0A Sweet Approach to Heat Up Cancer Response to Immunotherapy - 4 year(s) ago
Summary: Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies. See related article by Song et al., [p. 1872][1] . [1]: /lookup/volpage/10/1872?iss=12
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In the Spotlight: A sweet approach to heat up cancer response to #Immunotherapy, by @OliverMPearce and @Limmunotherapy. https://t.co/N8yIT8PrhJ https://t.co/SQkaugjw3t
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In this study, using a decellularized tissue model of ovarian cancer metastasis, the authors demonstrate that the extracellular matrix educates tumour-associated macrophages with an immunoregulatory phenotype. @DrEllyTyler, @pearce_lab, @LImmunotherapy https://t.co/42X8diUneR https://t.co/QlxFUmEOTP