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Mashup Score: 2iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2 - Nature Communications - 3 year(s) ago
Cells that cannot cope with persistent endoplasmic reticulum stress will die. Here, the authors show that iRhom pseudoproteases regulate cell death by modulating the ability of BCL-2 to inhibit calcium flow through IP3R channels.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies - Nature Communications - 3 year(s) ago
Influenza viruses carry their own RNAdependent RNA-polymerase that is highly conserved and a promising anti-viral target. Combining functional and structural data, Keown et al. characterise the inhibitory effect of nanobodies on 1918 pandemic H1N1 influenza strain polymerase complex and identify sensitive sites interfering with polymerase activity in vitro.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic #influenza virus using nanobodies @JeremyKeown1 @amandaz83411502 @Dunn_School @OxfordStrubi @UniofOxford @fodorlab @jonathan_grimes https://t.co/6nNV4GYFW9 https://t.co/RPqhviOyPy
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Mashup Score: 2Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies - Nature Communications - 3 year(s) ago
Influenza viruses carry their own RNAdependent RNA-polymerase that is highly conserved and a promising anti-viral target. Combining functional and structural data, Keown et al. characterise the inhibitory effect of nanobodies on 1918 pandemic H1N1 influenza strain polymerase complex and identify sensitive sites interfering with polymerase activity in vitro.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic #influenza virus using nanobodies @JeremyKeown1 @amandaz83411502 @Dunn_School @OxfordStrubi @UniofOxford @fodorlab @jonathan_grimes https://t.co/6nNV4HghkJ https://t.co/PYNZu4BzaN
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Mashup Score: 7Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Mammalian RNA polymerase II transcribes protein-coding genes and non-coding transcription units, including long non-coding RNAs (lncRNAs). Studies applying recently developed nascent transcriptomics technology have revealed differences in transcription initiation and termination between lncRNAs and protein-coding genes, bearing relevance to genomic stress and DNA damage.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
New #Review now live Insights into the regulation of #lncRNA transcription and processing Proudly delivered by Takayuki Nojima & Nick J. Proudfoot @Dunn_School @UniofOxford @KyushuUniv_EN #noncodingRNA https://t.co/KzjZTz1Dr3 https://t.co/4ZEGaWrG4g
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Mashup Score: 7Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal - Nature Communications - 3 year(s) ago
PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Chemical synthesis of linear and branched poly(ADP-ribose) molecules and structure-function analysis enable @JgmRack, Liu et al. to elucidate mechanistic differences between PARG and ARH3. @IvanAhelLab @Dunn_School @DrAntonioAriza https://t.co/vUY4bcHysj https://t.co/hlIMdyL8bW
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Mashup Score: 6Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal - Nature Communications - 3 year(s) ago
PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Chemical synthesis of linear and branched poly(ADP-ribose) molecules and structure-function analysis enable @JgmRack, Liu et al. to elucidate mechanistic differences between PARG and ARH3. @IvanAhelLab @Dunn_School @DrAntonioAriza https://t.co/vUY4bcZ9jR https://t.co/xtk2G2JhEC
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Mashup Score: 9LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages - 4 year(s) ago
Cowley et al. use patient, control, and gene-edited human iPSC macrophages/microglia to examine endogenous expression and function of the Parkinson’s disease gene, LRRK2, in this immune subset. LRRK2 is not involved in initial phagocytic uptake of bioparticles but is recruited to LAMP1+/RAB9+ “maturing” phagosomes and is required for RAB8a and RAB10 recruitment to phagosomes, linking phagosome…
Source: Stem Cell ReportsCategories: General Medicine News, Latest HeadlinesTweet-
Read a @stemcellreports article: LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages @ISSCR @martinperaJAX @Dunn_School https://t.co/1XOw5bKBYt https://t.co/owcWs1LTlk
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Mashup Score: 1Why do intestinal epithelial cells express MHC class II? - 4 year(s) ago
Intestinal epithelial cells (IECs) can express MHC class II molecules both at steady state and during inflammation, suggesting that they may shape local CD4+ T‐cell responses towards intestinal antig…
Source: Wiley Online LibraryCategories: Allergy-Immunology, Latest HeadlinesTweet-
Why do intestinal epithelial cells express MHC class II? In our cover article of the month, Cornelia Heuberger, Dr Johanna Pott & Prof @KJMaloy @Dunn_School @KirOxford @iiiglasgow explore the role of antigen presentation by #intestinalepithelialcells ➡️https://t.co/OBbgQkAiDd https://t.co/3bKdcFcTkp
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Mashup Score: 0
In this Review, Fodor and colleagues discuss recent structural insights into the RNA polymerases of negative-sense RNA viruses and their use to identify novel targets for the development of antiviral agents.
Source: Nature Reviews MicrobiologyCategories: Infectious Disease, Latest HeadlinesTweet-
📚 New in @NatureRevMicro! Drs. Aartjan te Velthuis (@aj_velthuis), Jonathan Grimes & Ervin Fodor compare structures of RNA polymerases of negative-sense RNA #viruses with segmented and non-segmented genomes. @Dunn_School 👁️ Full text https://t.co/WNslsXOori https://t.co/0GZhRQZaC8
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Mashup Score: 2Why do intestinal epithelial cells express MHC class II? - 4 year(s) ago
Intestinal epithelial cells (IECs) can express MHC class II molecules both at steady state and during inflammation, suggesting that they may shape local CD4+ T‐cell responses towards intestinal antig…
Source: Wiley Online LibraryCategories: Allergy-Immunology, Latest HeadlinesTweet-
Why do #intestinalepithelialcells express MHC class II? Great review from Cornelia Heuberger, Dr Johanna Pott & Prof @KJMaloy exploring the role of antigen presentation by IECs 👏 @Dunn_School @KirOxford @iiiglasgow #OpenAccess ➡️https://t.co/OBbgQkAiDd https://t.co/1UKlLYTD5y
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The lab of @mjafreeman shows that iRhom pseudoproteases regulate #ERstress induced #apoptosis by modulating the ability of BCL-2 to inhibit calcium flow through IP3R channels. @Dunn_School https://t.co/rPJKJ6MEno https://t.co/B81SqpDdnB