Therapeutic modulation of hypoxia-inducible factors, which transduce adaptive transcriptional responses to hypoxia, is an emerging theme in kidney disease. This Review summarizes the hypoxia signalling mechanisms underpinning these novel treatments and highlights key remaining questions relevant to their clinical use.
Drug repurposing, inspired by the Review on p707.
Nature Reviews Nephrology – Biomolecular condensates are membraneless compartments that typically contain proteins and RNAs and broadly affect many cell types and organs. In the…
Nature Reviews Nephrology – Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can…
Nature Reviews Nephrology – Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can…
Nature Reviews Nephrology – During disasters, the morbidity and mortality of patients with kidney disease far exceeds that of the general population. Here, the authors…
Nature Reviews Nephrology – The availability of antiretroviral therapy has led to a transformation in the spectrum of kidney diseases associated with HIV infection. This…
Nature Reviews Nephrology – This Review summarizes our current understanding of sex differences in renal fluid and electrolyte transporters, based primarily on studies in rodents.…
Nature Reviews Nephrology – Renal cell carcinoma is sensitive to immune checkpoint blockade despite having a moderate traditional tumour mutational burden profile. Here, the authors…
Nature Reviews Nephrology – Sex differences in immune cell function and immune responses affect the development and outcome of diverse diseases. Here, the authors review…
Nature Reviews Nephrology – The DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the…
