Intravascular haemolysis and the subsequent release of proinflammatory haemoglobin and haem into the circulation are characteristic of several diseases. This Review discusses the major pathophysiological mechanisms and consequences of intravascular haemolysis with a focus on the kidney, and highlights emerging therapeutic strategies to target haemolysis-related kidney injury.
Nature Reviews Nephrology – Despite advances in cell and gene therapy for the treatment of disease, no such interventions currently target the kidney. Here, the…
Nature Reviews Nephrology – The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackled unless kidney…
Nature – With rates rising around the world, public-health leaders must prioritize prevention, treatment, funding and data.
Nature Reviews Nephrology – The DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the…
Nature Reviews Nephrology – This Review summarizes the roles of sirtuins in kidney development, physiological processes and the pathogenesis of acute and chronic kidney diseases.…
Nature Reviews Nephrology – Despite advances in cell and gene therapy for the treatment of disease, no such interventions currently target the kidney. Here, the…
*Nature Reviews Nephrology* welcomes you to this webinar, in which our two speakers — Leo Celi and Kianoush Kashani — will present on the…
Nature Reviews Nephrology – Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Here, the…
*Nature Reviews Nephrology* welcomes you to this webinar, in which our two speakers — Leo Celi and Kianoush Kashani — will present on the…
Immune checkpoint inhibitors are increasingly used as anti-cancer treatments; however, their use can be associated with the development of immune-related adverse events, including acute kidney…
