MDM2 inhibition in a subset of sarcoma cell lines increases susceptibility to radiotherapy by inducing senescence in the polyploid cells

Management of liposarcoma, a subtype of soft-tissue sarcoma has been a clinical question. MDM2 inhibition by small molecule antagonists (Nutlin-3) lead to radio sensitivity to liposarcoma cell lines (with wild-type TP53 and amplified MDM2) by reactivating the p53. Co-treatment of nutlin-3 and radiation lead to ploidy-based heterogeneity with generation of polyploid cell. These polyploidy cells…

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