Localized- and advanced-stage follicular lymphomas differ in their gene expression profiles | Blood | American Society of Hematology
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Key PointsUnbalanced MYC break-apart FISH patterns, in which red or green signal is lost, are observed in ∼13% of HGBCL-DH-BCL2 tumors.Balanced and unbalan
Key PointsReal-world patients with lenalidomide-refractory MM and 1 to 3 prior LOT progress rapidly through therapies.Outcomes remain suboptimal, despite g
Key PointsDeletion of the α-globin genes induces a lethal phenotype associated with high levels of red blood cells in circulation.Transduction with a lenti
Key PointsAn inflammatory BMM with elevated levels of PGE2 accelerates the progression of PGE2-sensitive AML.A specific subset of patients with AML may ben
Key Points. Cumulative fracture incidence after R-CHOP in older patients (>70 years) is high (11.4% at 18 months).Bone involvement, prephase steroids, or eit
In this issue of Blood, Chappell et al describe a pair of innovations, a novel mouse model and an effective gene therapy approach, that renew prospects…
Key PointsA rare mutation in CXCR4 led to life-long autoimmunity and lymphoid hypertrophy in several members of a kindred.Lack of characteristic features o
Key PointsThe inability of T-PLL cells to evoke adequate P53 responses makes them vulnerable to inhibitors of (H)DAC, BCL2, CDK, and MDM2.Pharmacologic gen
Key PointsGilteritinib maintenance therapy after allogeneic HCT in FLT3-ITD AML is not associated with any difference in HRQOL compared with placebo.Despit
In this issue of Blood, Simonin et al propose a next-generation sequencing (NGS)-based risk classifier for patients with T-cell acute lymphoblastic leukemi