JCI – SARS-CoV-2: a storm is raging

The two coronaviruses that have been known to cause fatal pneumonia, SARS-CoV and MERS-CoV, are associated with rapid virus replication, an elevation of proinflammatory cytokines, and inflammatory cell infiltration (16). In SARS-CoV infection, it was immune dysregulation, rather than the level of peak viremia, that induced an insufficient type I interferon (IFN) response (too little and too…

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