ResearchIn-Press PreviewOncology Free access | 10.1172/JCI147849 Amruta S. Samant,1 Amin H. Nassar,2 Jonathan So,3 Elizabeth P. Garcia,4 Catherine R. Curran,3 Justin H. Hwang,3 David L. Mayhew,3 Anwesha Nag,5 Aaron R. Thorner,5 Judit Börcsök,6 Zsofia Sztupinszki,7 Chong-Xian Pan,2…
A video from Guru Sonpavde (as part of AdventHealth), posted on Apr 16, 2024.
Abstract Translocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show…
As a mitochondrial ETC inhibitor, metformin should theoretically be toxic, but it has a high safety profile, which is attributed to its reliance on organic…
Animals. Kinase-activating mutations were introduced into the SPAK gene, and expression of the CA form of SPAK was specifically targeted to the early DCT using…
Standard treatment. Women with OC are typically approached with tumor cytoreductive surgery, involving removal of gynecologic organs (total abdominal hysterectomy, bilateral salpingo-oophorectomy), lymph nodes, and…
Clinical MedicineIn-Press PreviewNeuroscience Open Access | 10.1172/JCI172460 Courtney Holmes,1 Patti Sullivan,1 Grisel Lopez,2 Janna Gelsomino,1 Sarah Moore,1 Risa Isonaka,1 Tianxia Wu,3 and Yehonatan Sharabi4 1Autonomic…
Complete absence of leptin or its inability to signal, caused by loss-of-function mutations of the ligand or its receptor in both rodents and humans, respectively,…
Complete absence of leptin or its inability to signal, caused by loss-of-function mutations of the ligand or its receptor in both rodents and humans, respectively,…
ResearchIn-Press PreviewNeuroscienceVascular biology Open Access | 10.1172/JCI166134 Russell H. Knutsen,2 Feiyang Ma,1 Ana Mompeón,1 Gloria E. Hernandez,1 Jocelynda Salvador,1 Snezana Mirkov,1 Ayush Batra,3 David P.…
Research ArticleOncology Open Access | 10.1172/JCI171199 Zengming Wang,2 Shengsong Huang,3 Dongyin He,1 Weiwei Yan,1 Qian Zhuang,1 Zixian Wang,4 Chenyang Wang,3 Qilong Tan,1 Ziqun Liu,1 Tao…
