Integration of prophages into CRISPR loci remodels viral immunity in Streptococcus pyogenes

CRISPR loci are composed of short DNA repeats separated by sequences that match the genomes of phages and plasmids, known as spacers. Spacers are transcribed and processed to generate RNA guides used by CRISPR-associated nucleases to recognize and destroy the complementary nucleic acids of invaders. To counteract this defense, phages can produce small proteins that inhibit these nucleases. Here…

Read the full article here

Source: bioRxiv
Categories: General Medicine Journals and Societies, Latest Headlines
Tags:
Tweets with this article
bioRxiv
Integration of prophages into CRISPR loci remodels viral immunity in Streptococcus pyogenes https://t.co/c5Fjt4JFMh #bioRxiv

Related Articles