Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a …
The role of autophagy in pulmonary microvascular endothelial cells (PMVECs) is controversial in LPS-induced acute lung injury (ALI). Mixed lineage kinase domain–like pseudokinase (MLKL) has…
Rationale: Cardiovascular events after chronic obstructive pulmonary disease (COPD) exacerbations are recognized. Studies to date have been post hoc analyses of trials, did not differentiate…
Background: Benzene affects human health through environmental exposure in addition to occupational contact. However, few studies have examined the associations between long-term exposure to low…
Rationale: Indigenous populations in the United States face numerous health disparities, but the health of Indigenous workers is less well understood. In a recent surveillance…
“.” American Journal of Respiratory and Critical Care Medicine, 209(7), pp. 782–784 Supported by NIH grants K08HL159353 and R03AG074056. Not Yet Registered? Benefits of Registration…
Benzene has been classified as a human carcinogen on the basis of evidence linking it to increased risks of acute myeloid leukemia in adults, as…
Rationale: The plasma lipidome has the potential to reflect many facets of the host status during severe infection. Previous work is limited to specific lipid…
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations of airways and…
Rationale: A recent randomized controlled trial revealed that a multicomponent sepsis transition and recovery (STAR) program delivered through specialized nurse navigators was effective in reducing…
Community-acquired pneumonia (CAP) with sepsis leads to over 350,000 ICU admissions in the United States annually, with an in-hospital mortality of 17% and a 1-year…
