PARP inhibitor monotherapies are effective to treat patients with breast, ovary, prostate, and pancreatic cancer with BRCA1 mutations, but not to the much more frequent BRCA wild-type cancers. Searching for strategies that would extend the use of PARP inhibitors to BRCA1-proficient tumors, we found that the stability of BRCA1 protein following ionizing radiation (IR) is maintained by…
Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer…
Abstract. Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small…
Abstract. The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of…
Abstract. Metastasis arises from cancer-cell intrinsic adaptations and permissive tumor microenvironments (TME) that are distinct across different organs. Deciphering the mechanisms underpinning organotropism could provide…
2023 Covers | Cancer Research | American Association for Cancer Research #aacr_embed_signup .aacr-field-group.input-group ul{list-style: none;} #aacr_embed_signup .aacr-field-group.input-group ul li{display: inline-block; width: fit-content; padding: 20px;} .inputsection…
Cancer Research | 84 | 8_Supplement | April 2024
Scientific publishing is a cornerstone of disseminating knowledge. One caveat of scientific publishing is that at any one time it is biased toward certain topics…
Cancer Research | 84 | 8 | April 2024
2023 Covers | Cancer Research | American Association for Cancer Research #aacr_embed_signup .aacr-field-group.input-group ul{list-style: none;} #aacr_embed_signup .aacr-field-group.input-group ul li{display: inline-block; width: fit-content; padding: 20px;} .inputsection…
Chronic stress stimulates cancer stemness by reducing the intestinal abundance of L. johnsonii and its metabolite PCA to enhance β-catenin signaling, forming a basis for…
