Rapid development of vaccines against SARS-CoV-2 led to substantial reductions in morbidity and mortality early in the pandemic. Concerns regarding waning immunity and the risk of emerging new variants, including Omicron, prompted recommendations for a third booster vaccine dose after completion of a 2-dose mRNA vaccine regimen, given its efficacy at further reducing risk for severe illness by up…
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR…
BACKGROUND: The SSaSS (Salt Substitute and Stroke Study) has shown that use of a potassium-enriched salt lowers the risk of stroke, total cardiovascular events, and…
Correspondence to: Cyndya Shibao, MD, Division of Clinical Pharmacology, Department of Med icine, Vanderbilt University Medical Center, Nashville, TN 3723. Division of Clinical Pharmacology, Department…
We address the reasons why, unlike other guidelines, in the 2023 guidelines of the European Society of Hypertension β-blockers (BBs) have been regarded as major…
BACKGROUND: The mechanisms by which salt increases blood pressure in people with salt sensitivity remain unclear. Our previous studies found that high sodium enters antigen-presenting…
BACKGROUND: The mechanisms by which salt increases blood pressure in people with salt sensitivity remain unclear. Our previous studies found that high sodium enters antigen-presenting…
BACKGROUND: The mechanisms by which salt increases blood pressure in people with salt sensitivity remain unclear. Our previous studies found that high sodium enters antigen-presenting…
Hypertension is one of the most commonly treated conditions in modern medical practice, but despite its long history, it was largely ignored until the midpoint…
BACKGROUND: Primary aldosteronism (PA) is frequently caused by a unilateral aldosterone-producing adenoma with a PA-driver mutation. Unilateral adrenalectomy has a high probability of short-term bioc
Correspondence to: Matthew R. Alexander, Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2215 Garland Ave, 560B RRB, Nashville, TN 37232. Email…
