Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β

Transforming growth factor–β (TGF-β) promotes fibrosis by stimulating fibroblasts to proliferate and differentiate into matrix-secreting myofibroblasts. Yin et al. found that the glycolytic enzyme hexokinase 2 (HK2) was highly abundant in lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and that TGF-β induced the accumulation of HK2 and stimulated glycolysis in mouse and…

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