Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Obesity is linked to white adipose tissue inflammation, but the causal factors remain unclear. Based on data obtained from clinical cohorts, mouse models, and cell cultures, Petrus et al. show that a reduction of adipose tissue glutamine levels in obesity leads to increased nuclear O-GlcNAcylation in adipocytes, which induces transcriptional activity of pro-inflammatory pathways.

Read the full article here

Related Articles