Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer

PURPOSE Genomic testing is recognized in national guidelines as essential to guide appropriate therapy selection in metastatic colorectal cancer. Previous studies report adherence to testing guidelines is suboptimal, but current testing rates have not been assessed. This study reports testing rates in metastatic colon cancer (mCC) for guideline-recommended biomarkers in a US-based population….

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Source: JCO Precision Oncology

Categories: Hem/Oncs

Tags: JCOPO

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Mike Thompson, MD, PhD, FASCO

Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer [Dec 6, 2019] @DrMartinEGutie1 et al. #JCOPO https://t.co/PnSiydvAuy #crcsm #PrecisionMedicine HT @stacywgray

Frontiers | Bone damage and health-related quality of life in Hodgkin lymphoma survivors: closing the gaps

In the recent decades, remarkable successes have been recorded in the treatment of Hodgkin’s lymphoma to the point that today it represents one of the…

Mike Thompson, MD, PhD, FASCO September 9, 2024

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Mike Thompson, MD, PhD, FASCO September 9, 2024

Prognostic Implications of Vitamin D in Patients With a Hematologic Malignancy at a Large Health System in Wisconsin

By Daniel Mundt, Marianne Klumph, Kayla Heslin, et al., Published on 05/26/21

Mike Thompson, MD, PhD, FASCO September 9, 2024

High incidence of fractures after R-CHOP-like chemotherapy for aggressive B-cell non-Hodgkin lymphomas

Supportive Care in Cancer – Patients with non-Hodgkin lymphoma (NHL) have a median age of 67, with 70% surviving over 5 years. Chemotherapy for aggressive…

Mike Thompson, MD, PhD, FASCO September 9, 2024

Osteonecrosis of the Jaw in Patients Receiving Zoledronic Acid for Bone Metastases

This cohort study defines the cumulative incidence of osteonecrosis of the jaw at 3 years in patients receiving zoledronic acid for metastatic bone disease from…

Mike Thompson, MD, PhD, FASCO September 9, 2024

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort

Osteoporosis International – In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant…

Mike Thompson, MD, PhD, FASCO September 9, 2024

Fractures are common within 18 months following first-line R-CHOP in older patients with diffuse large B-cell lymphoma

Key Points. Cumulative fracture incidence after R-CHOP in older patients (>70 years) is high (11.4% at 18 months).Bone involvement, prephase steroids, or eit

Mike Thompson, MD, PhD, FASCO September 9, 2024

Identification of non-Hodgkin lymphoma patients at risk for treatment-related vertebral density loss and fractures

Osteoporosis International – Information on bone loss in treated non-Hodgkin’s lymphoma patients is limited. In this study, we used CT to analyze bone loss as…

Mike Thompson, MD, PhD, FASCO September 9, 2024

Increased risk of osteoporosis following commonly used first-line treatments for lymphoma: a Danish Nationwide Cohort Study

High-dose prednisolone is used in first-line treatment for lymphoma, but the potential adverse impact on bone health is unclear. Danish patients with diffuse large B-cell…

Mike Thompson, MD, PhD, FASCO September 9, 2024

Low Bone Mineral Density and High Bone Turnover in Patients … : HemaSphere

Lymphoma (NHL). We prospectively evaluated bone remodeling pre- and post-chemotherapy in 61 patients with newly diagnosed NHL. First-line chemotherapy resulted in high bone turnover, which…

Mike Thompson, MD, PhD, FASCO September 9, 2024

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