Clinton et al. define the concordance of genomic alterations in urothelial carcinoma from a localized to metastatic state to identify drivers of progression. Within individual patients, there is significant discordance between primary and metastatic sites. Additionally, plasma cell-free DNA (cfDNA) can identify alterations not detected by tumor sequencing.
OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.
MSK has developed an arsenal of tests that are at the front lines of precision treatments. They target the structure of proteins that cause cancer,…
Valencia-Gallardo et al. show that the Shigella invasion effector IpaA induces major conformational changes in the vinculin head domain leading to vinculin oligomerization and actin filament…
Gunn et al. show that the commercially available Ebola virus vaccine leads to sustained protection in a macaque model of partial protection when antibodies are directed…
Bakouny et al. perform integrative genomic analyses of MiT/TFE-translocation renal cell carcinoma (tRCC) to define the hallmarks of this rare form of kidney cancer. They find…
Penfold et al. show that AMPK activation protects against prostate cancer progression in vivo. AMPK activation switches prostate cancer cells to a tumor-suppressive catabolic state, increasing PGC1α…
Cossec et al. show that chemical inhibition of SUMOylation in mouse embryonic stem cells produces self-assembled embryo-like structures with characteristics resembling a head and a trunk.…
Cox et al. show that AKT activation biases B cell development toward marginal zone (MZ) B cells with innate functions. CD148 is identified as a receptor…
Fang et al. report successful direct transdifferentiation of SSCs into iNSCs in vitro and show that inhibition of IκBα/β mRNA translation by m6A-mediated YTHDF1 LLPS is key…
A L97R substitution in the VP1 capsid protein of enterovirus A71, conferring heparan sulfate binding ability, was detected in an immunocompromised patient. Weng et al. demonstrate…
