Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
Longitudinal analysis of immune memory following mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.
Longitudinal analysis of immune memory following mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.
Zong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates…
The microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as β-lactamase in Bacteroides uniformis, and it alleviates MASH progression by…
Brown fat contributes to systemic glucose homeostasis by providing BCAA-nitrogen-derived metabolites, including glutathione, to the liver, a function that is distinct from the well-known role…
Spatial mapping shows that glioblastoma consists of both disorganized and structured regions. Structured regions display a five-layered organization that is associated with hypoxia and extends…
DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.
SARS-CoV-2 uses ORF6, a conserved protein among sarbecoviruses, to evade cytotoxic cell NKG2D recognition through a mechanism that results in the shedding of the surface…
Condensate-forming dual-action TFs are identified that reduce high expression but increase low expression of target genes to achieve stable intermediate levels, which is critical for…
The occupancy of ubiquitylation sites is very low and inherently constrained by the amount of ubiquitin molecules, resulting in an ubiquitylation system that operates with…
An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.
Pyroptosis is a form of signaling-induced cell death characterized by plasma membrane rupture. This study suggests a “cookie cutter”-like mechanism for pyroptotic cell lysis in…