Identifying cancer driver mutations is essential to understand disease biology and devise effective therapies, but remains a complex endeavor. A focused analytical approach is now presented that defines driver mutations affecting ubiquitin-mediated proteolysis through machine learning and mining of cancer multi-omics data.
Nature Cancer – Dotti and colleagues show that chimeric antigen receptor (CAR) natural killer T cells have superior antitumor activity compared with CAR-T cells, mediated…
Nature Cancer – Qui et al. perform co-detection by indexing profiling of 401 hepatocellular carcinoma patient samples and identify a role for vimentinhigh macrophages in…
Nature Cancer – Qui et al. perform co-detection by indexing profiling of 401 hepatocellular carcinoma patient samples and identify a role for vimentinhigh macrophages in…
Nature Cancer – Perro and colleagues develop a CD3+ T cell engager co-targeting BCMA and CD38 to improve immunotherapy for multiple myeloma, demonstrate cytotoxicity in…
Late registration is still available. Please reach out to events@embl.org to request it. This conference will take place at EMBL Heidelberg, with the option to…
Nature Cancer – Liang and colleagues establish a high-quality protein expression resource for 8,000 The Cancer Genome Atlas patient samples and 900 Cancer Cell Line…
Nature Cancer – Dimitriou et al. perform multiomic profiling of patients with melanoma experiencing immunotherapy-associated toxicity and identify a targetable role for type III-associated immune…
Nature Cancer – Rauh et al. developed a selective MCL1 inhibitor that is efficacious in hematological and solid tumors and has the advantage of limited…
The microbiota can influence the immune system and modulate response to cancer immunotherapy. In this webinar, our speakers will introduc…
Nature Cancer – Cheng and colleagues performed an integrative analysis of human colorectal cancer samples to characterize the tumor microenvironment (TME) and stratify patients according…
