Ellis and colleagues show that combination of EZH2 inhibition and anti-PD-1 can increase antitumor immune responses in typically ‘immune cold’ prostate cancer, by increasing EZH2-regulated dsRNA–STING–ISG response signaling.
A key challenge in the clinical management and cause of treatment failure of prostate cancer (PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems…
This study presents a significance analysis framework for evaluating single-cell clusters. Application of the method detects cases of over-clustering in reported single-cell RNA-sequencing analysis results.
ResearchIn-Press PreviewOncology Open Access | 10.1172/jci.insight.167440 Zhi Duan,2 Diana Flores,1 Chao Zhang,1 Archana Sehrawat,3 Ya-Mei Hu,4 Olivia A. Swaim,1 Eva Rodansky,1 William K. Storck,1 Joshua…
An engineered minimal cell evolves to escape the negative consequences of genome streamlining.
TFRI reached out to prostate cancer researcher Dr. Amina Zoubeidi to learn more about her cancer research journey, the lessons she’s learned along the way,…
RNA-guided systems, which employ complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic elements, play a central role in biological…
Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous…
Many biologists could benefit from using machine learning tools to analyze their data and inform their experiments, but few of them have the training required…
Regulatory circuits of gene expression can be represented as gene regulatory networks (GRNs) that are useful to understand cellular identity and disease. Here, the authors…
A technique called base editing has been used for the first time to treat human disease.
