Exploring the variance in complex traits captured by DNA methylation assays

Following years of epigenome-wide association studies (EWAS), traits analysed to date tend to yield few associations. Reinforcing this observation, we conducted EWAS on 400 traits and 16 yielded at least one association at the conventional significance threshold (P<1x10 -7). To investigate why EWAS yield is low, we formally estimated the proportion of phenotypic variation captured by 421,693...

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Source: bioRxiv
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