KRASG12C is an oncoprotein of high interest for drug development. Zeng et al. investigate targeting KRASG12C for degradation using small-molecule degraders (PROTACs) and document challenges and opportunities in this area.
Watson et al. show that multiple modes of therapy-induced glioblastoma regression are associated with fibrosis, which promotes tumor cell survival. Using multi-omics analyses, they identify the…
Christina Kashiwada was traveling for work during the summer of 2018 when she noticed a small, itchy lump in her left breast.
Scientists have discovered that PFAS, a group of human-made chemicals, are being released as gases from landfills at alarming rates.
Everyone thought he was the professor. But the gray-haired older man was a freshman medical student — just like the rest of the class.
Nature Communications – Histone H3-mutant gliomas are deadly brain tumours and the tumour microenvironment is not fully understood. Here the authors profile the immune microenvironment…
During carcinoma metastasis, malignant progenitors undergo a TGF-β-dependent EMT associated with fibroblast activation and extracellular matrix remodeling in the tumor microenvironment. RAS-activated RREB1 primes enhancers…
Aging-driven and sex-dependent molecular changes in skin fibroblasts drive the emergence of invasive and therapy-resistant melanomas in male mice.
Welcome to YOUR Sheet Music Library! All the music you want to play on one site. Subscribe, download and play! The Sheet Music Library (PDF),…
Dozens of health care providers and community members sent an open letter warning of issues at South County Hospital.
The new Mass General Brigham Cancer will account for the total health of the patient, not just the cancer itself.
